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KMID : 0880520060420010039
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Chonnam Medical Journal
2006 Volume.42 No. 1 p.39 ~ p.43
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Tumor Necrosis Factor-a,Interleukin-6 and Interleukin-8 Levels in Tears of Patients with Keratoconus
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You In-Cheon
Heo Hwan
Yoon Kyung-Chul
Park Yeoung-Geol
Jung Young-Do
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Abstract
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To investigate whether chronic inflammatory process is involved in the pathogenesis of keratoconus, the levels of tumor nerosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and interleukin-8 (IL-8) were determined in tears of patients with keratoconus. TNF-alpha, IL-6 and IL-8 levels were measured by enzyme-linked immunosorbent assay in tear samples obtained from 9 keratoconus patients and 5 control subjects. The relative expression of TNF-alpha, IL-6 was evaluated in conjunctival biopsy specimens using immuno-histochemical staining. The mean levels of TNF-alpha, IL-6 and IL-8 were 5.31+/-3.67, 5.82+/-2.26 and 480.10+/-141.80 pg/ml respectively in keratoconus patients, whereas they were 4.95+/-3.04 (p=0.89), 5.30+/-1.94 (p=0.69) and 433.13+/-154.01 (p=0.44) pg/ml in the control subjects, revealing no differences between both groups. Immunohistochemical staining showed no positive staining for TNF-alpha and Il-6 in keratoconus patients. These findings indicate that the pathogenesis of keratoconus may not involve chronic inflammatory events
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KEYWORD
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Keratoconus, Tear, Tumor necrosis factor-a, Interleukin-6, Interleukin-8
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